The Science of RVO

The Science of RVO focuses on increasing global public awareness of retinal vein occlusion (RVO), the role of VEGF (vascular endothelial growth factor) in vision loss due to CRVO, and the benefits of anti-VEGF treatments for patients with CRVO.


The Angiogenesis Foundation built this resource to provide accurate, easy to understand, and useful information about the evidence supporting anti-VEGF therapy for RVO. We believe everyone affected by RVO can be empowered with knowledge of relevant treatments and the practical steps they can take to fight vision loss.
Use this resource to learn:


  • How RVO can lead to severe or even permanent vision loss
  • Why early treatment is important for saving your vision
  • The role of VEGF in vision loss due to RVO
  • Evidence on the benefit of anti-VEGF therapy for CRVO patients
  • Future directions for treating RVO

The Angiogenesis Foundation

The Angiogenesis Foundation is the world’s first nonprofit organization dedicated to conquering disease using a groundbreaking approach based on angiogenesis, the growth of new capillary blood vessels in the body.


The Foundation is the recognized authority on the field of angiogenesis, championing new treatments to combat blindness and preserve vision.


We share this expertise to endow the public with important knowledge about their health. Understanding the science behind RVO and its treatment will guide patients, their advocates and doctors to understand modern treatments and the need for evidence-based, proactive care and regularized treatments.


Based in Cambridge, Massachusetts and founded in 1994, the Angiogenesis Foundation’s goal is to help people lead healthier, longer lives by restoring balance to blood vessel growth. Through research, education and advocacy—with patients, physicians, researchers, industry, payers and government—we enable patients to gain access to safe and effective treatments for vision loss disorders, cancer, wound healing complications and many other serious diseases.


As a scientific organization, the Angiogenesis Foundation is independent of any individual, institution or commercial entity. We are committed to helping people around the world benefit from the full promise of angiogenesis-based medicine and to make life-, limb-, and vision-saving treatments available to everyone in need.

Our Mission

The mission of the Angiogenesis Foundation is to improve health around the world through education and advocacy, so that patients can be empowered to take an active role in fighting RVO. We work with RVO patients, their advocates and their healthcare providers around the world to disseminate knowledge about anti-VEGF treatments for RVO in order to improve patient outcomes.

This website will guide you, as a person with RVO, in understanding your condition and the treatment options available to prevent vision loss. Know how to take an active role in managing your condition and choosing the best treatment for you.

Take Action

This Science of RVO resource empowers you to take the necessary steps for understanding your condition and seeking the best treatment options:


  • GET the facts about RVO and how vision loss progresses
  • SEE an eye care professional to assess if you have, or are at risk, for RVO
  • BE in control of your health by taking the necessary steps to monitor your vision and get the best treatment for you.